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Science - Research Articles
- Developmental clock and mechanism of de novo polarization of the mouse embryo
胚胎极化时钟反映了合子基因开始激活,鉴定了三个基因和下游分子通路
- Genetic interaction mapping informs integrative structure determination of protein complexes
点突变对应的表型谱,根据后者相似性鉴定出位置接近的残基对,来预测蛋白质结构
- Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites
多能干细胞长成具有神经管和体节的东西,可以类比研究胚胎发育
- CiBER-seq dissects genetic networks by quantitative CRISPRi profiling of expression phenotypes
CRISPR 高通量,barcoded reporter,在整合压力应答(ISR)通路中,既重复了传统的 uncharged tRNA 途径,又发现了新的 tRNA 不足途径
- A transmissible cancer shifts from emergence to endemism in Tasmanian devils
用流行病学方法研究袋獾肿瘤,R 从之前的 3.5(预测灭绝)降到了目前的 1 左右
- Recent global decline of CO2 fertilization effects on vegetation photosynthesis
CO2 多,植物长得好,固定更多 CO2,但这个良性循环在百年尺度上是减弱的
- Monolithic perovskite/silicon tandem solar cell with >29% efficiency by enhanced hole extraction
高性能串联太阳能电池
Science - Reports
- Optically addressable molecular spins for quantum information processing
旋转子 for 量子计算
- Reversible planar gliding and microcracking in a single-crystalline Ni-rich cathode
单晶服镍阳极,观察到一种现象,为降低**损耗提供线索
- Protein condensates as aging Maxwell fluids
麦克斯韦流体
- Resonant collisional shielding of reactive molecules using electric fields
控制分子间相互作用 for 量子计算。。人为使反应速率降低一个数量级
- Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
发现一种表型,tumor-infiltrating lymphocytes (TIL)细胞可以分为两类
- Indian monsoon derailed by a North Atlantic wavetrain
中纬度的 Rossby 波影响印度季风
- Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
感染前就已经有新冠免疫力,但是抗体种类和丰度与感染者不同
- The evolution of a tropical biodiversity hotspot
恶劣环境下物种产生的速度更快,但是热带地区在时间尺度累积、形成丰富的生物多样性
- Southern Ocean upwelling, Earth’s obliquity, and glacial-interglacial atmospheric CO2 change
Nature
- Detection of large-scale X-ray bubbles in the Milky Way halo
- Unveiling the strong interaction among hadrons at the LHC
- Dipolar evaporation of reactive molecules to below the Fermi temperature
- Operation of an optical atomic clock with a Brillouin laser subsystem
原子钟从微波到光波级,作者开发了不需要真空的系统
- Capillary condensation under atomic-scale confinement
开尔文方程描述了毛细现象,当管径与水分子大小可比时肯定没戏。。等等,作者发现居然是对的,巧合而已,真实原因是管的弹性形变
- Catalytic asymmetric addition of an amine N–H bond across internal alkenes
- Quantification of an efficiency–sovereignty trade-off in climate policy
碳税怎么收?作者认为最好是在统一定价的基础上加适当扰动,辅以适当财政转移
- Clustered versus catastrophic global vertebrate declines
物种灭绝速率用的是平均数,作者发现受极端值的干扰非常严重
- Late Cretaceous bird from Madagascar reveals unique development of beaks
- Multiple wheat genomes reveal global variation in modern breeding
15个小麦基因组比较
- The barley pan-genome reveals the hidden legacy of mutation breeding
20个大麦品种基因组,提出 pan基因组来反映序列多样性
- PIEZO2 in sensory neurons and urothelial cells coordinates urination
PIEZO2 基因控制撒尿
- Chemico-genetic discovery of astrocytic control of inhibition in vivo
蛋白质组学发现分子机制
- The gut microbiota is associated with immune cell dynamics in humans
从接受治疗的癌症病人取样,1万份肠道基因组样本,分析其变化与免疫细胞变化的关系
- LDLRAD3 is a receptor for Venezuelan equine encephalitis virus
CRISPR 筛选出病毒依赖的宿主因子
- Sex differences in immune responses that underlie COVID-19 disease outcomes
为什么男性得新冠后病情更重,是因为免疫反应的不同
- Tunable dynamics of B cell selection in gut germinal centres
- Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
spike 蛋白两次剪切,电镜研究分子机制
- A metastasis map of human cancer cell lines
体内 barcode 研究癌症转移
- A map of cis-regulatory elements and 3D genome structures in zebrafish
在斑马鱼中把各种组学都做了一遍
- Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
- Structures and pH-sensing mechanism of the proton-activated chloride channel
Cell