Science - Research Articles

1. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 13个loss-of-function 突变位点，控制 TLR3与IRF7依赖的I类干扰素免疫力，严重的COVID-19症状
2. Autoantibodies against type I IFNs in patients with life-threatening COVID-19 大佬就是喜欢发两篇，这次 title 都几乎一样，自身抗体
3. Design of higher valency in covalent organic frameworks 有机体用碳，4价根本不够玩，造个8价甚至无限价的
4. Deep abiotic weathering of pyrite 黄铁矿氧化，不是生物体的锅
5. De novo design of picomolar SARS-CoV-2 miniprotein inhibitors 计算机设计多肽，最好的两种是结合spike蛋白的一种新 binding 模式，电镜结构与预测几乎一模一样
6. Orderly compartmental mapping of premotor inhibition in the developing zebrafish spinal cord 发育的时间顺序，决定了神经微回路的空间顺序，分别控制由快至慢的运动

Science - Reports

1. Polyethylene upcycling to long-chain alkylaromatics by tandem hydrogenolysis/aromatization 分解塑料产烃
2. Supertwisted spirals of layered materials enabled by growth on non-Euclidean surfaces
3. Triple iron isotope constraints on the role of ocean iron sinks in early atmospheric oxygenation 铁能耗氧，亦能产氧，后者更多
4. Structural basis of nucleosome-dependent cGAS inhibition 3.3A不行啊，cGAS 伤敌一千（外源DNA），多亏核小体管住才不会自损八百
5. Structural basis for the inhibition of cGAS by nucleosomes 换了作者就看不出来是重发了吗，题目那么像
6. Metasurface-driven OLED displays beyond 10,000 pixels per inch 视网膜屏太low了，1万像素就看你怕不怕，nanopatterned metasurface mirrors
7. Lineage analysis reveals an endodermal contribution to the vertebrate pituitary
8. Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota
9. Social selectivity in aging wild chimpanzees 社会选择性在黑猩猩中就存在，不需要复杂的面向未来的认知能力
10. Experimental evolution makes microbes more cooperative with their local host genotype

Nature

1. Stellar clustering shapes the architecture of planetary systems 发现离系外恒星很近的 stellar groups，可以分析其影响。
2. Integrated optical multi-ion quantum logic scalable optics co-fabricated
3. Integrated multi-wavelength control of an ion qubit
4. Toughening mechanisms of the elytra of the diabolical ironclad beetle 仿生一种甲虫，研究其鞘翅是如何融合不同的材料，概念验证
5. Filling metal–organic framework mesopores with TiO2 for CO2 photoreduction 制作“分子隔间”，让 TiO2 在孔洞内生长
6. Seismic evidence for partial melt below tectonic plates
7. A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures 改造新冠病毒 spike 蛋白，使其感染老鼠，建立动物模型
8. SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness mRNA 把 spike 蛋白困在感染前的状态。
9. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity 受体结合结构域 RBD，319–545 残基
10. ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques 腺病毒载体，spike 蛋白
11. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques 单次注射就能保护
12. Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults mRNA 疫苗。由于不良反应，第二针没有打。
13. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses above 同一项工作，细胞和分子层面的结果
14. The genomic landscapes of individual melanocytes from human skin 单细胞基因组，持续晒比间歇晒的突变更少，累计突变可以表征光损害和癌症风险，皮肤实际上是由“菌落”拼起来
15. Immune-evasive human islet-like organoids ameliorate diabetes 胰岛类器官，过表达PD-L1来躲避免疫系统，能重建血糖稳态达 50 天。
16. A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation 鉴定有袋类和胎盘类分化之前就已经保守的，胚胎发育和 X 剂量补偿机制。
17. Regulation of the MLH1–MLH3 endonuclease in meiosis 同源重组中如何控制切 DNA
18. PCNA activates the MutLγ endonuclease to promote meiotic crossing over 滑动钳 PCNA 对 crossover-biased resolution 很重要