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50周:Dec11 Science, Dec10 Nature, Dec10 Cell

Science - Research Articles

  1. Developmental clock and mechanism of de novo polarization of the mouse embryo 胚胎极化时钟反映了合子基因开始激活,鉴定了三个基因和下游分子通路
  2. Genetic interaction mapping informs integrative structure determination of protein complexes 点突变对应的表型谱,根据后者相似性鉴定出位置接近的残基对,来预测蛋白质结构
  3. Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites 多能干细胞长成具有神经管和体节的东西,可以类比研究胚胎发育
  4. CiBER-seq dissects genetic networks by quantitative CRISPRi profiling of expression phenotypes CRISPR 高通量,barcoded reporter,在整合压力应答(ISR)通路中,既重复了传统的 uncharged tRNA 途径,又发现了新的 tRNA 不足途径
  5. A transmissible cancer shifts from emergence to endemism in Tasmanian devils 用流行病学方法研究袋獾肿瘤,R 从之前的 3.5(预测灭绝)降到了目前的 1 左右
  6. Recent global decline of CO2 fertilization effects on vegetation photosynthesis CO2 多,植物长得好,固定更多 CO2,但这个良性循环在百年尺度上是减弱的
  7. Monolithic perovskite/silicon tandem solar cell with >29% efficiency by enhanced hole extraction 高性能串联太阳能电池

Science - Reports

  1. Optically addressable molecular spins for quantum information processing 旋转子 for 量子计算
  2. Reversible planar gliding and microcracking in a single-crystalline Ni-rich cathode 单晶服镍阳极,观察到一种现象,为降低**损耗提供线索
  3. Protein condensates as aging Maxwell fluids 麦克斯韦流体
  4. Resonant collisional shielding of reactive molecules using electric fields 控制分子间相互作用 for 量子计算。。人为使反应速率降低一个数量级
  5. Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer 发现一种表型,tumor-infiltrating lymphocytes (TIL)细胞可以分为两类
  6. Indian monsoon derailed by a North Atlantic wavetrain 中纬度的 Rossby 波影响印度季风
  7. Preexisting and de novo humoral immunity to SARS-CoV-2 in humans 感染前就已经有新冠免疫力,但是抗体种类和丰度与感染者不同
  8. The evolution of a tropical biodiversity hotspot 恶劣环境下物种产生的速度更快,但是热带地区在时间尺度累积、形成丰富的生物多样性
  9. Southern Ocean upwelling, Earth’s obliquity, and glacial-interglacial atmospheric CO2 change


  1. Detection of large-scale X-ray bubbles in the Milky Way halo
  2. Unveiling the strong interaction among hadrons at the LHC
  3. Dipolar evaporation of reactive molecules to below the Fermi temperature
  4. Operation of an optical atomic clock with a Brillouin laser subsystem 原子钟从微波到光波级,作者开发了不需要真空的系统
  5. Capillary condensation under atomic-scale confinement 开尔文方程描述了毛细现象,当管径与水分子大小可比时肯定没戏。。等等,作者发现居然是对的,巧合而已,真实原因是管的弹性形变
  6. Catalytic asymmetric addition of an amine N–H bond across internal alkenes
  7. Quantification of an efficiency–sovereignty trade-off in climate policy 碳税怎么收?作者认为最好是在统一定价的基础上加适当扰动,辅以适当财政转移
  8. Clustered versus catastrophic global vertebrate declines 物种灭绝速率用的是平均数,作者发现受极端值的干扰非常严重
  9. Late Cretaceous bird from Madagascar reveals unique development of beaks
  10. Multiple wheat genomes reveal global variation in modern breeding 15个小麦基因组比较
  11. The barley pan-genome reveals the hidden legacy of mutation breeding 20个大麦品种基因组,提出 pan基因组来反映序列多样性
  12. PIEZO2 in sensory neurons and urothelial cells coordinates urination PIEZO2 基因控制撒尿
  13. Chemico-genetic discovery of astrocytic control of inhibition in vivo 蛋白质组学发现分子机制
  14. The gut microbiota is associated with immune cell dynamics in humans 从接受治疗的癌症病人取样,1万份肠道基因组样本,分析其变化与免疫细胞变化的关系
  15. LDLRAD3 is a receptor for Venezuelan equine encephalitis virus CRISPR 筛选出病毒依赖的宿主因子
  16. Sex differences in immune responses that underlie COVID-19 disease outcomes 为什么男性得新冠后病情更重,是因为免疫反应的不同
  17. Tunable dynamics of B cell selection in gut germinal centres
  18. Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion spike 蛋白两次剪切,电镜研究分子机制
  19. A metastasis map of human cancer cell lines 体内 barcode 研究癌症转移
  20. A map of cis-regulatory elements and 3D genome structures in zebrafish 在斑马鱼中把各种组学都做了一遍
  21. Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction
  22. Structures and pH-sensing mechanism of the proton-activated chloride channel