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22周,May29 Science, May28 Nature, May28 Cell

1 Science - Research Articles

  1. Self-induced spin glass state in elemental and crystalline neodymium 钕, new spin glass state, 解决钕的磁性争论,
  2. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells NK和杀伤性T细胞,granzymeA 进入表达GSDMB的细胞,切割产生的 N端能在细胞膜打孔,诱导发炎,杀死肿瘤
  3. Biotic interactions drive ecosystem responses to exotic plant invaders 外来植物入侵一般会引起碳循环效率增加,文章发现主要原因是与土壤微生物和食草植物相互作用。
  4. *The human tumor microbiome is composed of tumor type–specific intracellular bacteria 测序,免疫组化,确认存活。物种特异性、功能特异性。
  5. Synthesis of proteins by automated flow chemistry 流式自动化学合成长达 164aa 的肽链只用数小时(ribosome几分钟),九个单domain蛋白质的活性媲美生物
  6. Strengthening of the Kuroshio current by intensifying tropical cyclones 热带气旋加强涡旋位?
  7. Electrogenetic cellular insulin release for real-time glycemic control in type 1 diabetic mice 无线电信号控制基因表达或蛋白质分泌,使糖尿病老鼠恢复正常。钾通道降低静息电位,电压门控钙通道作开关。

2 Science - Reports

  1. Control of zeolite pore interior for chemoselective alkyne/olefin separations 把镍固定到六元环控制催化剂内孔径分离烷烃/烯烃
  2. Total synthesis of bryostatin 3 依靠烷烃使用原子效率高、化学选择转换,缩短了总步骤和最长路径
  3. Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model 恒河猴,SARS-CoV-2 无症状从鼻到喉且被检测到,SARS-CoV 肺部感染更严重
  4. Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2 狗、猪、鸡、鸭复制很慢,但白鼬和猫易感
  5. Delicate seafloor landforms reveal past Antarctic grounding-line retreat of kilometers per year 自动水下装置记录地平线移动速度

3 Nature

  1. A census of baryons in the Universe from localized fast radio bursts 样本足够大到 account for 观测的 variation
  2. Spectroscopy of short-lived radioactive molecules 解决了放射性分子不稳定的难题
  3. Stable, high-performance sodium-based plasmonic devices in the near infrared 用新金属材料制作性能更好的光传感器
  4. Seeded growth of large single-crystal copper foils with high-index facets 高维晶体铜土壤能储存更多、更复杂的信息
  5. Photocatalytic water splitting with a quantum efficiency of almost unity 在350~360nm范围内催化剂光解水的效率达到96%
  6. A general carbonyl alkylative amination for tertiary amine synthesis 新的合成方法:把 alkyl 自由基加到某离子上
  7. Skeleton of a Cretaceous mammal from Madagascar reflects long-term insularity 挖掘出最完整的中生代岗得瓦纳古陆哺乳动物标本
  8. Olfactory sniffing signals consciousness in unresponsive patients with brain injuries 嗅觉和基本感情共用部分大脑结构,可以通过测试前者来判定脑损伤患者是否拥有意识。最神的是,能闻的人一定能恢复意识
  9. *The mutational constraint spectrum quantified from variation in 141,456 humans 预测 loss-of-function 受到注释错误和频率极低的困扰,所以作者搞了 16k基因组和126k外显组
  10. A structural variation reference for medical and population genetics sequence-resolved 的结构变异的参考 map
  11. Transcript expression-aware annotation improves rare variant interpretation 可变剪接导致 isoform 的表达量不一样,所以 putative loss-of-function 可能会有不同的表型
  12. Virological assessment of hospitalized patients with COVID-2019 病毒在上呼吸道活跃复制
  13. The stepwise assembly of the neonatal virome is modulated by breastfeeding 揭示了新生儿的病毒组是如何形成的,先是温和的噬菌体,然后是人类病毒,母乳能有效抑制后者
  14. Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells 细菌代谢胆汁酸,产生很多类固醇,促进 CD4+ line
  15. Origin of complexity in haemoglobin evolution 血红蛋白是如何从单体进化来的,两个substitutions就足以从同源二聚体变成异源四聚体

4 Cell

  1. Coast-to-Coast Spread of SARS-CoV-2 during the Early Epidemic in the United States 西海岸到东海岸,国内传播比国际更重要
  2. Genomic Epidemiology of SARS-CoV-2 in Guangdong Province, China 本地传播被有效切断,而外省输入在增加
  3. Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies 靶向必需的 spike 蛋白,因为其识别宿主受体、介导膜融合
  4. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues 果然原代细胞才是最好的,细胞系一般,小鼠更是差远了
  5. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19 在 SARS-CoV-2 中,宿主的抗病毒转录效应更低
  6. Structural and Proteomic Characterization of the Initiation of Giant Virus Infection 低 pH 释放蛋白质,加上高温完全释放基因组
  7. Unblending of Transcriptional Condensates in Human Repeat Expansion Disease 串联重复改变相分离、和沉淀辅激活因子的能力
  8. Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells 微生物诱导传统树突细胞进入战斗准备状态
  9. The Penium margaritaceum Genome: Hallmarks of the Origins of Land Plants 基因复制产生新功能,适应陆生
  10. *Molecular Choreography of Acute Exercise 结果当然可以分析一大堆,既有与之前的(特定组分)研究相符,也有不符的,但感觉没有连贯的主线,也没有统一的结论。
  11. A Paleogenomic Reconstruction of the Deep Population History of the Andes 古人类基因流动
  12. The Genomic History of the Bronze Age Southern Levant 后青铜迁移
  13. Genomic History of Neolithic to Bronze Age Anatolia, Northern Levant, and Southern Caucasus 近东
  14. Visualizing and Modulating Mitophagy for Therapeutic Studies of Neurodegeneration 高通量筛选线粒体自噬