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42周：Oct16 Science, Oct15 Nature, Oct15 Cell

Posted on 4 mins read

Science - Research Articles

  1. Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue 细胞是如何控制自身大小，顶端压力纤维 aSF定位在紧密连接处，其数量与细胞顶端区域成正比，aSF 反过来又能调控 Hippo 通路
  2. Behavioral state coding by molecularly defined paraventricular hypothalamic cell type ensembles 体内对同一个单细胞进行钙成像和 RNA-seq，发现marker gene组合能预测神经元反应
  3. The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior 细胞核能起到感应细胞自身大小的功能，细胞核被拉伸时，内核膜 unfold，用钙信号控制 actomyosin 收缩和迁移粘性
  4. The nucleus acts as a ruler tailoring cell responses to spatial constraints 与上一篇同一工作，细胞核作为 ruler 感应周围空间限制，上调收缩性，介导细胞迁移。展示了细胞如何通过狭窄通道 restrictive pore，与癌细胞扩散，免疫反应，胚胎发育都有关。
  5. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense 脂质体参与哺乳动物先天免疫，在LPS诱导下，既组织免疫蛋白杀死病原体，调节代谢来适应感染。
  6. Microbiota-modulated CART+ enteric neurons autonomously regulate blood glucose 回肠和结肠的神经元比十二指肠的对微生物更敏感，其中 CART+ 神经元轴突下游调控血糖，这一过程看起来不用中枢参与。
  7. Patterning and growth control in vivo by an engineered GFP gradient GFP和抗GFP的纳米小体可以形成浓度梯度，把后者连接到天然形态发生素Dpp的受体，然后GFP就可以控制形态发生。加上GPI之后几乎和野生型一样，但没有明确为什么需要 GPI。

Science - Reports

  1. Engineering synthetic morphogen systems that can program multicellular patterning 还是一稿发两篇，不过这次两篇类型不一样。形成人造 pattern 后，分析了哪些因素能改变 gradient，哪些因素能改变对 gradient 的响应。
  2. Coherently forming a single molecule in an optical trap 控制超冷单分子很困难，作者通过另一种途径，把两个原子 bind 到弱作用分子
  3. Cartilage-inspired, lipid-based boundary-lubricated hydrogels 以关节软骨为灵感，在水凝胶表面加了一层薄薄的脂质
  4. Zeptosecond birth time delay in molecular photoionization 光电离有delay，之前发现 10^-18 秒级别，作者发现 10^-21 秒，因为在同一轨道的电子也不是同时的（旅行时间有差异）
  5. Thermosensitive crystallization–boosted liquid thermocells for low-grade heat harvesting 收集100℃以下的热量
  6. Species richness and redundancy promote persistence of exploited mutualisms in yeast 实验验证，丰富冗余的群落更容易在剥削中存活下来
  7. The GATOR–Rag GTPase pathway inhibits mTORC1 activation by lysosome-derived amino acids 蛋白质降解后的氨基酸通过 HOPS 复合体调节 mTORC1，并且被 GATOR–Rag 负调节（后者本来正调节 mTORC1）
  8. Structural and spectroscopic characterization of an Fe(VI) bis(imido) complex 光合作用中高价铁很多，但六价铁却很少见，纯化学分析
  9. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor GS-6207 为什么能抗 HIV-1 呢？同时结合两个衣壳亚基，不让他们解离；同时抑制与胞内辅因子的结合。
  10. Comprehensive quantification of fuel use by the failing and nonfailing human heart 分析了心脏靠哪些代谢物供能。很多结论。心脏主要消耗氨基酸而不是葡萄糖，受损的心脏消耗更多的酮体和乳酸。

Nature

  1. H I 21-centimetre emission from an ensemble of galaxies at an average redshift of one
  2. Room-temperature superconductivity in a carbonaceous sulfur hydride 室温超导，高压下 H2S 到 H3S
  3. A system hierarchy for brain-inspired computing 类脑计算完备性
  4. Efficient and stable blue quantum dot light-emitting diode 蓝光量子点
  5. Surface coordination layer passivates oxidation of copper 铜表面钝化
  6. Building cratonic keels in Precambrian plate tectonics
  7. Environmental drivers of megafauna and hominin extinction in Southeast Asia 同位素测年研究南亚物种灭绝
  8. Amygdala inhibitory neurons as loci for translation in emotional memories 蛋白质翻译指导抑制神经元做出危险或安全的反应
  9. eIF2α controls memory consolidation via excitatory and somatostatin neurons 翻译起始因子影响长时程记忆
  10. Negative feedback control of neuronal activity by microglia 小胶质细胞就像抑制性神经元一样
  11. Relatives of rubella virus in diverse mammals 麻疹病毒也许是从动物园来的
  12. STING cyclic dinucleotide sensing originated in bacteria 蛋白质结构
  13. A STAT3 palmitoylation cycle promotes TH17 differentiation and colitis 可逆转录后修饰，分子机制
  14. MeCP2 links heterochromatin condensates and neurodevelopmental disease MeCP2 分隔常染色质和异染色质
  15. C. elegans interprets bacterial non-coding RNAs to learn pathogenic avoidance 线虫对致病菌说：小样，你化成灰（sRNA）我都认得你
  16. Structural basis for dimerization quality control 细胞的监管可比央妈严多了，不仅要检查蛋白质折叠，还要看二聚体对不对，这个例子是检查分子间 β-sheet
  17. Structural basis for pH gating of the two-pore domain K+ channel TASK2

Cell

  1. Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly BCG对孩子有用，那么对老人有用吗？
  2. Maternal Fecal Microbiota Transplantation in Cesarean-Born Infants Rapidly Restores Normal Gut Microbial Development: A Proof-of-Concept Study 破腹产打乱了肠道微生物组的传递？那就移植粪便来恢复
  3. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness 根据骨骼肌与心肌的肌球蛋白的关键单残基差异，开发 MPH-220，舒张肌肉治疗痉挛和僵直
  4. A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer 癌细胞突变后可以产生新的抗原靶点 neoantigen，这里讲了一种药物
  5. Noninvasive Early Identification of Therapeutic Benefit from Immune Checkpoint Inhibition 体液检测 ctRDNA 等能在早期预测哪些病人有持久好疗效
  6. Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma 肿瘤微环境很像胚胎的重编程
  7. Regulation of Collective Metastasis by Nanolumenal Signaling
  8. Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption 巨噬细胞会监测大肠吸收的液体，避免摄入真菌毒素
  9. High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models phage display，文库筛选
  10. The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism X-ray 结构 dock 进 11.4A 的 TOM，小老弟不行啊
  11. Dual Functions of a Rubisco Activase in Metabolic Repair and Recruitment to Carboxysomes 光合作用关键酶 Rubisco 会被糖磷酸抑制，作者揭示了 Rca 是如何把它修好的
  12. Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism Mg2+ 稳态是如何调节的呢？作者揪出了 Lactate
  13. Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation PTPN11 激活和抑制突变的疾病为何会有相似的症状？原来是 common 液-液相分离行为
  14. A Global Map of G Protein Signaling Regulation by RGS Proteins 20 种 G蛋白信号调节蛋白 RGS 分别与 16中 Gα的反应活性，以及控制其活性的机制
  15. A Thalamic Orphan Receptor Drives Variability in Short-Term Memory 200 只老鼠 GWAS，5号染色体的某个 locus 与 working memory 显著相关，其中编码一个孤儿 G 蛋白偶联受体
  16. Local Axonal Conduction Shapes the Spatiotemporal Properties of Neural Sequences 神经元为什么能依次激活？局部轴突减速线(delay lines)