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03周:Jan22 Science, Jan21 Nature, Jan21 Cell

Science - Research Articles

  1. JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications 电镜复合体结构,揭示蛋白质作用机制
  2. Developmental cell programs are co-opted in inflammatory skin disease 单细胞测序,发现 reemergence of 。。。cellular programs
  3. Regulation of the Dot1 histone H3K79 methyltransferase by histone H4K16 acetylation 组蛋白修饰的 cross-talk
  4. Bifurcation of planetary building blocks during Solar System formation 行星为什么是分两拨生成的?because 原行星盘的演化和雪线的迁移

Science - Reports

  1. Ultrafast nanoimaging of the order parameter in a structural phase transition 电镜,看到相转变
  2. Unraveling CO adsorption on model single-atom catalysts Keeping Z-olefins intact with iridium
  3. Iridium-catalyzed Z-retentive asymmetric allylic substitution reactions Modeling single-atom reactivity
  4. Convergent evolution of pain-inducing defensive venom components in spitting cobras 趋同演化,三个眼镜蛇支系都演化出了,对付敌人的毒液(本来毒液是主要用于捕猎的)
  5. Nanoscale localized contacts for high fill factors in polymer-passivated perovskite solar cells effective passivation 和 excellent charge extraction 我全都要
  6. Transvection regulates the sex-biased expression of a fly X-linked gene 性二态一般是由sex determination 的遗传机制来控制,作者发现一个基因是通过其它机制控制的
  7. Host succinate is an activation signal for Salmonella virulence during intracellular infection 沙门氏菌感应到巨噬细胞的琥珀酸盐积累之后,解放自己的毒力
  8. Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity A metabolic circuit in T cell immunity
  9. Clock genes and environmental cues coordinate Anopheles pheromone synthesis, swarming, and mating
  10. Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast balance 选择让酵母保留了两条不兼容的半乳糖通路


  1. Observation of the onset of a blue jet into the stratosphere 国际空间站的观测数据
  2. Trapped fractional charges at bulk defects in topological insulators
  3. Bulk–disclination correspondence in topological crystalline insulators 同上,这篇强调对拓扑晶体材料进行分类
  4. A reprogrammable mechanical metamaterial with stable memory 记忆金属只能记住一个形状,作者直接改造成像硬盘一样随意读写
  5. Transporting and concentrating vibrational energy to promote isomerization 荧光共振能量转移,那振动(vibration)也能转移
  6. A stable low-temperature H2-production catalyst by crowding Pt on α-MoC 只要挨得近,就不用担心氧使催化剂灭活
  7. Lake heatwaves under climate change heatwave是指某些时段湖的表面非常热,用历史卫星数据预测了全球变暖之后的变化(完全不讲原因啊)
  8. High sensitivity of tropical precipitation to local sea surface temperature local。 很难与 global。 区分开。。但作者发现 local。 对气候模型非常重要
  9. Mapping routine measles vaccination in low- and middle-income countries 麻疹疫苗接种数据,地理高精度,2000~2019
  10. Boundary-anchored neural mechanisms of location-encoding for self and others 大脑不仅要知道主人的位置,也要知道其他人的位置。。底层 encode 机制有相似性
  11. A brainstem peptide system activated at birth protects postnatal breathing 新生儿的第一次呼吸需要神经系统的支持。。敲除发现了重要基因
  12. Pairing of segmentation clock genes drives robust pattern formation 想要两个基因协同表达,既可以在染色体临近,也可以共用调控因子。。作者只证明体节分化必须靠前者,并没有从原理上阐明前者的选择优势
  13. Arterialization requires the timely suppression of cell growth 动脉形成不是靠。。而是靠 Notch通路来启动动脉分化程序,而是考抑制表皮细胞周期
  14. RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy 胸腺。。免疫。。胚胎着床
  15. Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis
  16. Sorting nexin 5 mediates virus-induced autophagy and immunity 基因组短 RNAi 筛选
  17. Measuring DNA mechanics on the genome scale loop-seq,测量 DNA 的机械性质
  18. Design of biologically active binary protein 2D materials 一种蛋白能形成二维膜。。作者设计两种蛋白,形成二维膜
  19. A non-hallucinogenic psychedelic analogue with therapeutic potential 化学修饰,把迷幻剂变成治疗成瘾的良药


  1. Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy 快速、便携。检测新冠RNA
  2. A modular master regulator landscape controls cancer transcriptional identity 基因组突变如何影响转录组identity
  3. FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells 发现 FBXO44 在癌症细胞抑制重复元素(RE)的转录
  4. Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates 五个 3A 电镜。。一种抗癌药机理
  5. Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer 剪接错误的 RNA 能够诱导抗肿瘤
  6. Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma scRNA,肝癌复发早期的immune evasion机制
  7. A basophil-neuronal axis promotes itch 痒,肿瘤,神经回路
  8. Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential scRNA,如题
  9. Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques 新冠药物的机制
  10. COVID-19-neutralizing antibodies predict disease severity and survival 新冠,病情重,抗体高,中和高,potency低
  11. Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks 在神经元encoding 研究中,加入细胞类别信息(scRNA)
  12. A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila 果蝇,冲动,神经机制。。既有性同态,也有性二态
  13. Structural basis of γ-secretase inhibition and modulation by small molecule drugs 药物针对 γ-secretase 治疗阿尔兹海默,γ-secretase 分别结合两种药物的电镜结构
  14. KCNE1 is an auxiliary subunit of two distinct ion channel superfamilies KCNE1 作为 auxiliary subunit 脚踩两条船,挑战离子通道分类的教条